Scientists say they should soon be able to effectively cure inherited, life-threatening heart muscle conditions to save more young people from sudden cardiac death.
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The British Heart Foundation has pledged 30m to the gene researchers who believe they can correct faulty DNA responsible for the damage.
Cardiomyopathies can kill without warning.
Many members of the same family are often at risk due to their genetics.
Cardiomyopathies often hit the headlines when they result in sudden cardiac death or heart emergencies in young, elite athletes.
Sport can exacerbate an underlying condition.
Footballer Fabrice Muamba collapsed on the pitch aged 23 because of heart problems during a game for Bolton in 2012. Doctors managed to resuscitate him, but others - like 28-year-old Cameroon soccer star Marc-Vivien Foe - have died.
The research team who have been given the grant say they are confident that their gene therapy could be ready for testing in human clinical trials within five years, now that the genes and specific genetic faults responsible for different cardiomyopathies, and how they work, have been uncovered.
They have already been doing groundwork in animals and human cells.
Delivered through an injection in the arm, the therapy could halt heart damage in those already living with genetic cardiomyopathies, they say.
And it could prevent the disease developing in family members who carry a faulty gene but have not yet developed the condition - effectively curing the problem.
